Half of the titular duo's role is explained in detail: Zack happens upon the talking skull of Barbaros, who promises to get Zack "the world's treasure" in return for help lifting a curse. Players guide Zack through various environments and stages, solving puzzles and such along the way. The Wii Remote will be used to rotate handles, turn keys to open doors, play a piccolo, and more. The remainder of the duo, Wiki, has it even better: he's a flying monkey.
Zack & Wiki is shooting for a fall release.